| Theme |
Recent advances in research concerning FGF23 and Klotho |
| Title |
The significance of FGF23 from the perspective of epidemiological data |
| Author |
Takayuki Hamano |
Clinical Epidemiology Unit, Center for Clinical Epidemiology and Biostatistics, University of Pennsylvania, Perelman School of Medicine |
| [ Summary ] |
It was recently found that FGF23 levels predict not only future refractory secondary hyperparathyroidism in hemodialysis patients but also hard outcome. FGF23 levels predict mortality in patients with coronary artery disease Summary (CAD) and all stages of chronic kidney disease (CKD) (predialysis, incident and prevalent dialysis, and after transplantation phase). Despite inconsistent results in its association with vascular calcification, the association of FGF23 levels with left ventricular mass index and endothelial dysfunction are confirmed in the general population as well as predialysis CKD patients. The association with left ventricular hypertrophy is compatible with a recent experimental finding that FGF23 itself induces cardiac hypertrophy. Moreover, FGF23 levels predict cardiovascular events in patients with CAD and predialysis CKD. FGF23 is also a predictor of renal outcome in patients with transplantation as well as patients with CKD. |