| Theme |
Recent advances in research concerning FGF23 and Klotho |
| Title |
FGF23 and hypophosophatemic diseases |
| Author |
Itsuro Endo |
Endocrinology and Metabolism, Faculty of Medicine, The University of Tokushima Hospital |
| [ Summary ] |
Through the studies of patients with hypophosphatemic rickets/osteomalacia, FGF23 has emerged as a humoral factor which reduces serum phosphate levels. The discovery of FGF23 as an essential regulator of phosphate homeostasis has markedly improved our understanding of phosphate homeostasis and hypophosphatemic or hyperphosphatemic disorders. Measurement of circulatory FGF23 levels seems to be useful for diagnosing these disorders. Novel therapeutic methods for these disorders may be developed by elucidation of the mechanisms of FGF23 actions. |