| Theme |
Outcomes of CKD Campaign and Future Treatments Concerning CKD and Dialysis |
| Title |
Miyagi Gonryo CKD study |
| Author |
Mariko Miyazaki |
Division of Blood Purification, Tohoku University Hospital / Division of Nephrology, Endocrinology and Vascular Medicine, Tohoku University Graduate School of Medicine |
| Author |
Masaaki Nakayama |
Department of Nephrology and Hypertension, Fukushima Medical University School of Medicine |
| Author |
Emiko Miyazawa |
Division of Nephrology, Endocrinology and Vascular Medicine, Tohoku University Graduate School of Medicine |
| Author |
Tae Yamamoto |
Division of Blood Purification, Tohoku University Hospital |
| Author |
Tasuku Nagasawa |
Division of Nephrology, Endocrinology and Vascular Medicine, Tohoku University Graduate School of Medicine |
| Author |
Masato Matsushima |
Division of Clinical Epidemiology, The Jikei University |
| Author |
Toshinobu Sato |
Department of Nephrology, Sendai Shakaihoken Hospital |
| Author |
Hiroshi Sato |
Division of Clinical Pharmacy, Tohoku University Graduate School of Medicine |
| Author |
Toshio Taguma |
Department of Nephrology, Sendai Shakaihoken Hospital |
| Author |
Sadayoshi Ito |
Division of Nephrology, Endocrinology and Vascular Medicine, Tohoku University Graduate School of Medicine |
| [ Summary ] |
Chronic kidney disease (CKD) consists of symptoms covering a broad range of pathophysiology because it is simply confirmed by serum creatinine and urinary findings. We conducted a prospective cohort, "the Miyagi Gonryo CKD Study," to clarify the relationship between renal pathophysiology and cardiovascular disease. The subjects of this study were outpatients of the nephrological departments in Miyagi prefecture in North East Japan. During the five year follow-up period, the primary endpoint consisted of all-causes of death, including end stage kidney disease and cardiovascular events. Baseline analysis tracked actual CKD management of blood pressure, anemia, and urinary acid considered as risk factors for vascular disease. A one-year interim analysis revealed that underlying diseases such as diabetic nephropathy or hypertensive nephropathy affected outcomes more than primary renal diseases. The role of underlying vascular lesions in patients who were hypertensive or who had diabetic nephropathy may be important in relation to cardiovascular events. This study highlights the nephrological view of cardiovascular event in CKD patients and suggests further beneficial strategic for CKD management by nephrologists. |