| Theme |
How Can We Realize the Philosophy of Chronic Kidney Disease-Mineral and Bone Disorder? |
| Title |
Control of parathyroid hyperplasia in CKD-MBD |
| Author |
Masatomo Taniguchi |
Department of Medicine and Clinical Science, Graduate School of Medical Sciences, Kyushu University |
| Author |
Masanori Tokumoto |
Department of Medicine, Fukuoka Dental College |
| [ Summary ] |
The concept of "chronic kidney disease-mineral and bone disorder (CKD-MBD)" treatment is centered on avoiding mortality. From the viewpoint of CKD-MBD treatment, it is of great importance to prevent parathyroid gland hyperplasia in order to maintain proper serum calcium, phosphate and parathyroid hormone levels over the long term. Qualitative and quantitative changes in nodular-type parathyroid hyperplasia are considered to be irreversible. Because of this it is better to inhibit parathyroid cell proliferation from the early stages of secondary hyperparathyroidism. The mechanisms of parathyroid hyperplasia are extrapolated and elucidated in relation to prevention of parathyroid gland growth. |