臨牀透析 Vol.24 No.4(2-3)


特集名 透析医療における臨床研究の現状と課題
題名 透析合併症 (3) 透析困難症
発刊年月 2008年 04月
著者 池江 亮太 湘南鎌倉総合病院腎臓内科
著者 小林 修三 湘南鎌倉総合病院腎臓内科
【 要旨 】 透析困難症はしばしば経験される合併症で,その原因評価が重要である.患者側の要因として,心機能障害,自律神経機能障害,低アルブミン血症,貧血などがあり,治療者側の要因として,不適切なdry weight,透析膜の生体不適合性,降圧薬の影響,透析液の汚染などがある.このうち,適正なdry weightの設定についてはbioelectorical impedance analysis (BIA) の有用性が期待される.
Theme Current Problem of Clinical Studies in Dialysis Therapy
Title Dialysis-related hypotension
Author Ryota Ikee Department of Nephrology and Kidney and Dialysis Center, Shonan Kamakura General Hospital
Author Shuzo Kobayashi Department of Nephrology and Kidney and Dialysis Center, Shonan Kamakura General Hospital
[ Summary ] Dialysis-related hypotension, a frequent complication in clinical practice of hemodialysis, is attributable to several causes, such as cardiac complications, autonomic dysfunction, hypoalbuminemia, anemia, inappropriate dry weight, low dialyzer biocompatibility, antihypertensive drugs, and increased endotoxin concentrations in dialysis fluids. Cardiac complications are important, because they are associated with high mortality rates for dialysis patients. In addition, it should be noted that a substantial percentage of asymptomatic patients have coronary artery stenosis, as proven by coronary angiography at the initiation of dialysis. The assessment of appropriate dry weight is another important problem. Although there is no standardized method to determine appropriate dry weight to date, bioelectrical impedance analysis, which can evaluate extracellular volume, intracellular water, and total body water, seems to be a promising method.
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