| Theme |
Biocompatibility on Materials for Dialysis Equipments and Devices |
| Title |
Biocompatibility of cellulose triacetate membrane dialyzer with microgradient porous structure |
| Author |
Fumihiko Koiwa |
Division of Nephrology, Department of Internal Medicine, Showa University Fujigaoka Hospital |
| Author |
Junko Neishi |
Division of Nephrology, Department of Internal Medicine, Showa University Fujigaoka Hospital |
| Author |
Yoshinori Sato |
Department of Clinical Engineering, Showa University Northern Yokohama Hospital |
| [ Summary ] |
A microgradient porous structure, composed of a skin layer on the inner surface, supported by a porous sponge layer, shows high solute permeability for both small molecular and low molecular proteins. A newly developed cellulose triacetate (CTA) membrane, with a microgradient porous structure, was compared with a conventional polysulfone (PS) membrane dialyzer. A high clearance of beta2 microgloblin was observed in both membranes, and was greater than in the conventional CTA dialyzer, although there was less albumin loss into the dialysate than with the PS. As for biocompatibility, a transient drop in white blood cell count and a gradual increase in granulocyte elastase were observed in both conventional CTA and new CTA during HD. Complement C3a was also increased transiently at 15 min after the start of HD, and recovered at the end of HD, however these changes were comparable with the PS. These examinations revealed that a new CTA membrane dialyzer, with a porous gradient structure, showed high dialytic performance and excellent biocompatibility without using polyvinylpyrrolidone. |