| Theme |
New Turn of Acute Blood Purification |
| Title |
Endogenous cannabinoids, ANA and 2-AG were the pathological mediators of acute hemocatharsis therapy |
| Author |
Tomonori Uchimura |
Laboratory and Vascular Medicine, Cardiovascular and Respiratory Disorders, Advanced Therapeutics, Kagoshima University, Graduate School of Medical and Dental Sciences |
| Author |
Ikuro Maruyama |
Laboratory and Vascular Medicine, Cardiovascular and Respiratory Disorders, Advanced Therapeutics, Kagoshima University, Graduate School of Medical and Dental Sciences |
| [ Summary ] |
The existence of exogenous cannabinoid receptors, CB1 and CB2 has been demonstrated. The endogenous agonists of cannabinoid receptors have been identified as the anandamide (ANA) and 2-arachidonoyl glycerol (2-AG). Recently, ANA and 2-AG have been considered to exert, effects on cardiovascular actions, such as being contributors to endotoxin induced hypotension. Direct hemoperfusion (DHF) with an endotoxin adsorbent column, using polymyxin B-immobilized fiber (PMX-F) has been shown to improve the condition of patients with septic shock. Very recently, we demonstrated that polymyxin B absorbs ANA and 2-AG at high affinity rates in vivo and in vitro. These two lipid mediators, ANA and 2-AG were very important substances in therapeutic targeting and the pathogenesis of endotoxin shock. |