臨牀透析 Vol.17 No.8(2-6)


特集名 透析患者における感染症学 ---- 診断と治療の進歩
題名 特殊な病態における感染症 (6) 泌尿器疾患を有する患者
発刊年月 2001年 07月
著者 中川 健 慶應義塾大学医学部泌尿器科学教室
著者 村井 勝 慶應義塾大学医学部泌尿器科学教室
【 要旨 】 透析患者では,その感染防御機能の低下から,感染症が問題となり,死亡原因の第2位を占める.そして,尿量の減少が避けられない透析患者では,尿路感染症が重大な問題となることが多い.さらに,泌尿器疾患に合併する場合,複雑性尿路感染症の病態をとり,治療に難渋,重症化することも少なくない.嚢胞性腎疾患,とくに多発性嚢胞腎での感染が高率に認められるが,尿流停滞を生じるような尿路閉塞性疾患や機能性疾患についても十分に把握しておくことが大切である.尿路閉塞性疾患としては,透析患者の高齢化に伴う尿路悪性腫瘍や前立腺肥大症,機能的尿停滞疾患としては,糖尿病に伴う神経因性膀笳などは,現在の透析患者背景を考えると,泌尿器科医以外の透析医においても,ある程度知っておくべき疾患である.複雑性尿路感染症において,感染治療のみならず,原疾患に対する迅速な対応が必要となることが少なくないのである.
Theme Infections Diseases in Hemodialysis Patients -- the Progress of Diagnosis and Therapy
Title Infections disease in dialysis patients with urological diseases
Author Ken Nakagawa Department of Urology, Keio University School of Medicine
Author Masaru Murai Department of Urology, Keio University School of Medicine
[ Summary ] Since the host defense mechanisms are impaired in dialysis patients, infections become difficult to control and represent the second major cause of death. Additionally, because a reduction in urine volume cannot be avoided in such patients, most of them develop urinary tract infections, which become the main therapeutic problem. If these infections co-exist with a urological disease, complicated urinary tract infection may develop, and this frequently retards treatment and changes a patient's state into a severe illness. Although a high infection rate is observed in cystic renal disease, especially in polycystic kidneys, a total understanding of disorders that cause urine retention, like urinary tract obstruction and functional disorders, is crucial. This concerns not only urologists but also other specialists dealing with dialysis and, to some extent, it should be understood that advanced-age dialysis patients with obstructive uropathy develop urinary tract malignant tumors and/or prostatic hypertrophy, and diabetic patients with functional urinary tract obstruction suffer from neurogenic bladder and/or similar pathologies. If a patient on dialysis develops a complicated urinary tract infection, the patient may require prompt therapeutic response not only to the infection, but also to the primary disease.
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