| Theme |
Recent advances in the diagnostic imaging and the treatment of liver metastates from colorectal cancer |
| Title |
Adjuvant chemotherapy for the liver metastases from colorectal cancer |
| Author |
Shigenori Honma |
Department of Surgery, Tokyo Metropolitan Komagome Hospital |
| Author |
Takeo Mori |
Department of Surgery, Tokyo Metropolitan Komagome Hospital |
| Author |
Keiichi Takahashi |
Department of Surgery, Tokyo Metropolitan Komagome Hospital |
| Author |
Tatsuo Yamaguchi |
Department of Surgery, Tokyo Metropolitan Komagome Hospital |
| [ Summary ] |
1731 patients with colorectal cancer were treated in our hospital from 1990 to 1999. 122 patients had unresectable liver metastases from colorectal cancer. Patients with unresectable liver metastases received 24-hour continuous arterial infusion therapy of 5-FU 250 mg/body/day every two weeks. The one-year-survival-rate for the unresectable liver metastases from colorectal cancer was 55.8%. The two-year-survival rate was 11.2% Three cases (2.4%) had complete responses, 70 cases (57.8%) had partial responses. 19 cases (15.7%) saw no change, 29 cases (23.9%) got progressively worse. The response rate for hepatic artery infusion (HAI) therapy is 60.3%. Furthermore, we were able to perform surgical resection of metastatic residual lesion in patients who responded to 5-FU arterial infusion. Twenty one cases (17.2%) were treated with surgical resection after HAI therapy. The 3 year survival rate of the resection after HAI group was 42.3%, the same rate as the unresected group is 4.0%. The 5-year-survival rate of the resection after HAI group was 21.2%. the same rate of unresectable group is 0% (p<0.0001). Resection after HAI is a new strategy for unresectable liver metastases resultiog from colorectal cancer. We must treat HAI continuously after liver resection to prevent the recurrence of remnant liver cancer. |