| Theme |
Molecular pathology of colorectal cancer for clinicians |
| Title |
Hereditary non-polyposis colorectal cancer(HNPCC) |
| Author |
Taiji Furukawa |
Department of Surgery, Jichi Medical School |
| Author |
Fumio Konishi |
Department of Surgery, Jichi Omiya Medical Center |
| Author |
Kazuhisa Shitoh |
Department of Surgery, Jichi Medical School |
| Author |
Hideo Nagai |
Department of Surgery, Jichi Medical School |
| Author |
Toshihiko Tsukamoto |
Department of Pharmacology, Kitasato University |
| [ Summary ] |
Hereditary non-polyposis colorectal cancer(HNPCC) is an autosomal dominant inherited disease, characterized by early onset age, rightsided predominance, increased incidence of synchronous and metachronous colorectal cancers as well as endometrial, urinary tract, small-bowell, and gastric cancers. Currently, diagnosis of HNPCC is dependent on the criteria proposed by the International Collaborative Group on HNPCC, known as the "Amsterdam Criteria." However, because this criteria is so stringent, the Japanese Clinical Criteria has been used in this country. |