| Theme |
Modality and new development in diagnosis for colorectal tumor -- with the aim of the improvement of a presence and qualitative diagnosis |
| Title |
Ultra-magnifying endoscopy, current status and prospects |
| Author |
Yuichi Mori |
Digestive Disease Center, Showa University Northern Yokohama Hospital |
| Author |
Shin-ei Kudo |
Digestive Disease Center, Showa University Northern Yokohama Hospital |
| Author |
Kunihiko Wakamura |
Digestive Disease Center, Showa University Northern Yokohama Hospital |
| Author |
Masashi Misawa |
Digestive Disease Center, Showa University Northern Yokohama Hospital |
| Author |
Toyoki Kudo |
Digestive Disease Center, Showa University Northern Yokohama Hospital |
| Author |
Kenichi Takeda |
Digestive Disease Center, Showa University Northern Yokohama Hospital |
| Author |
Katsuro Ichimasa |
Digestive Disease Center, Showa University Northern Yokohama Hospital |
| Author |
Haruhiro Inoue |
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| Author |
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| [ Summary ] |
Recently, two types of ultra-magnifying endoscopes have been applied to clinical practice enabling us to provide in vivo cellular observation. These are the Endocytoscope (EC ; CF-Y0058, Olympus, Tokyo) and Confocal laser endomicroscope (CLE ; Cellvizio, Mauna Kea Technologies, Paris). EC employs an endoscope, on the tip of which a microscopic lens is attached, allowing visualization of cellular lumens, nuclei, and vessels with 500 fold magnification. On the other hand, CLE is a probe-based laser endoscope which analyzes the excitation light emitted by fluorescein in the mucosa, allowing visualization of cellular lumens and vessels with 1,000 fold magnification. Both EC and CLE provide higher diagnostic performance in pathological prediction of colorectal polyps in comparison to other previously developed endoscopes. Due to these strengths, these endoscopes are expected to bring about the "future of medicine", namely EC being applied to automated diagnostic systems powered by artificial intelligence, while CLE can be used for endoscopic molecular imaging. |