| Theme |
Inflammation and cancer in the lower GI tract |
| Title |
Treatment of colitis-associated colorectal cancer (CRC) : Artifice in surgical therapy for large intestines |
| Author |
Hiroki Ikeuchi |
Department of Inflammatory Bowel Disease Surgery, Hyogo College of Medicine |
| Author |
Motoi Uchino |
Department of Inflammatory Bowel Disease Surgery, Hyogo College of Medicine |
| Author |
Hiroki Matsuoka |
Department of Inflammatory Bowel Disease Surgery, Hyogo College of Medicine |
| Author |
Toshihiro Bando |
Department of Inflammatory Bowel Disease Surgery, Hyogo College of Medicine |
| Author |
Kei Hirose |
Department of Inflammatory Bowel Disease Surgery, Hyogo College of Medicine |
| Author |
Akihiro Hirata |
Department of Inflammatory Bowel Disease Surgery, Hyogo College of Medicine |
| Author |
Teruhiro Chono |
Department of Inflammatory Bowel Disease Surgery, Hyogo College of Medicine |
| Author |
Hirofumi Sasaki |
Department of Inflammatory Bowel Disease Surgery, Hyogo College of Medicine |
| [ Summary ] |
Similar to ordinary colon cancer, colectomy with lymph node dissection is often performed for carcinoma of the large intestine associated with ulcerative colitis (UC). For rectal cancer, it is important to determine if sphincter-preserving surgery is possible. Patient prognosis is generally not poor, as they tend to show improvement with this treatment. On the other hand, it is difficult to make a diagnosis prior to surgery in patients with Crohn's disease (CD), and it is not uncommon for cancer to be confirmed upon examination of a resected specimen. In Japan, CD often coexists with an anorectal lesion, which typically requires abdominoperineal resection of the rectum. A complex anal fistula is frequently seen as a comorbid condition ; thus, the extent of resection is difficult to determine in the perineal area. These patients generally have a poor prognosis, as the cancer is frequently progressive. |