| [ Summary ] |
Recently, the etiology of Behçet's disease, as a multi-factorial disease, has been analyzed using the genome-wide association study (GWAS) technique. As a result, many susceptible genes related to Behçet's disease have been identified, including Th1 related genes other than susceptible genes, such as HLA-B51. The development of future studies on ERAP (endoplasmic reticulum aminopeptidase) requires examination of the following points : first, ERAP is an enzyme involved in trimming peptides before fitting them to HLA；second, high synergy effects are seen in association with frequency of risk associated with alleles in HLA-B51-positive cases. Moreover, the concept of auto-inflammation has recently gained attention as an etiology associated with Behçet’s disease. Genes play a central role in auto-inflammation, including IL-1 and the MEFV, which have also been identified as disease susceptible genes. |