| Theme |
Laterally spreading tumor (LST) -- Toward a new era |
| Title |
Genetic characteristics of laterally spreading tumors |
| Author |
Sakiko Hiraoka |
Department of Gastroenterology and Hepatology, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences |
| Author |
Keita Harada |
Department of Endoscopy, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, |
| Author |
Jun Kato |
Second Department of Internal Medicine, Wakayama Medical University |
| [ Summary ] |
Each granular type of laterally spreading tumor (LST-G), including non-granular type LST (LSTNG) and sessile serrated adenoma/polyp (SSA/P), are characterized by superficial expansion along the colonic lumen. They are considered to have unique genetic characteristics associated with carcinogenesis. RAS/RAF/MAPK signals and the frequency of DNA methylation have been shown to be involved in correlations between morphologic difference in LSTs and genetic alterations. The representative molecular changes of LST-G, LST-NG, and SSA/P are K-ras mutation/CIMP-low, K-ras wild/BRAF wild/CIMP-negative, and BRAF mutation/CIMP-high, respectively. |