INTESTINE Vol.14 No.5(1)


特集名 内科医にわかってほしいクローン病の外科治療
題名 クローン病の自然史と治療の変遷
発刊年月 2010年 09月
著者 長坂 光夫 藤田保健衛生大学消化管内科
著者 平田 一郎 藤田保健衛生大学消化管内科
【 要旨 】 クローン病は難治性の原因不明の疾患であり未だ根本治療がない.これまでの抗炎症薬と栄養療法では着実に治療しても寛解─再発・再燃の負のサイクルを断ち切ることはできずに再手術,再々手術となる例が多かった.近年の生物学的製剤の開発による分子標的治療の普及で患者QOLは著しく向上し,新たに粘膜治癒と再燃・再発の予防の概念が確立し,内科治療のみならず外科手術に関してまでも治療のあり方が変わろうとしている.
Theme Surgical therapy for Crohn's disease -- Essentials for physician
Title The change of the treatment and the natural history in the Crohn's disease
Author Mitsuo Nagasaka Department of Gastroenterology, Fujita-Health University School of Medicine
Author Ichiro Hirata Department of Gastroenterology, Fujita-Health University School of Medicine
[ Summary ] The cause of Crohn's disease is unknown and treatment is difficult, and there is no radical treatment. At this time, it is not possible to break the cycle of recurrence-remission of this disease. Crohn's disease has been treated with anti-inflammatory agents and nutrition therapy, with limited degrees of efficacy. Repeated operations are often performed to treat it. Recently, biologic agents to treat Crohn's disease have produced very good results, providing improved patient quality of life. By establishing the concept of mucosal healing and relapse prevention, with medical treatment as well as surgery, we may provide improved treatment for this condition.
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