| Theme |
Revaluation of de nove cancer |
| Title |
Epigenetic alterations in carcinogenesis of de novo colorectal cancer |
| Author |
Eiichiro Yamamoto |
First Department of Internal Medicine, Sapparo Medical University |
| Author |
Hiro-o Yamano |
Division of Gastroenterology, Akita Red Cross Hospital |
| Author |
Yasuhisa Shinomura |
First Department of Internal Medicine, Sapparo Medical University |
| Author |
Minoru Toyota |
Department of Biochemistry, Sapparo Medical University, Sapparo Medical University |
| [ Summary ] |
Epigenetic alterations play important roles in the development of carcinogenesis and are related to geneticalterations. The profile of epigenetic and genetic alterations related to colorectal cancer (CRC) are divided into three different subclasses : the CpG island methylator phenotype (CIMP) 1, CIMP2 and CIMP-negative. It is suspected that de novo CRC is CIMP-negative andis associated with p53 mutation and loss of heterozygosity. |