臨牀消化器内科 Vol.34 No.2(1-1)


特集名 胆囊癌診療の現況
題名 胆囊癌の疫学 (1) 日本と世界の発生動向
発刊年月 2019年 02月
著者 澤田 雄 横浜市立大学消化器・腫瘍外科学
著者 松山 隆生 横浜市立大学消化器・腫瘍外科学
著者 藪下 泰宏 横浜市立大学消化器・腫瘍外科学
著者 本間 祐樹 横浜市立大学消化器・腫瘍外科学
著者 熊本 宜文 横浜市立大学消化器・腫瘍外科学
著者 遠藤 格 横浜市立大学消化器・腫瘍外科学
【 要旨 】 日本は国際的に見て,胆囊癌の多発国で,診断時年齢の最多は70歳代と比較的高齢である.また女性に多いが,性差は近年縮小している.胆囊癌は国際的にも女性に多く,ホルモンとの関連が示唆されている.世界の国,地域別の特徴として,チリ女性に突出して多く発生し,インドや東欧,東アジアなどが好発地域と知られている.これまでに地域や人種に関連した多くの危険因子についての報告があるが,疫学的ならびに分子生物学的な解明は未だ進んでいない.今後の研究から,将来の予防対策が進むことを期待したい.
Theme The Current Status of Management of Gallbladder Cancer
Title Epidemiology of Gallbladder Cancer -- Incidence Trends in Japan and the World
Author Yu Sawada Department of Gastroenterological Surgery, Graduate School of Medicine, Yokohama City University
Author Ryusei Matsuyama Department of Gastroenterological Surgery, Graduate School of Medicine, Yokohama City University
Author Yasuhiro Yabushita Department of Gastroenterological Surgery, Graduate School of Medicine, Yokohama City University
Author Yuki Homma Department of Gastroenterological Surgery, Graduate School of Medicine, Yokohama City University
Author Takafumi Kumamoto Department of Gastroenterological Surgery, Graduate School of Medicine, Yokohama City University
Author Itaru Endo Department of Gastroenterological Surgery, Graduate School of Medicine, Yokohama City University
[ Summary ] Japan's gallbladder cancer incidence is among the highest in the world. In Japan, the most frequent age to be diagnosed with gallbladder cancer is in the 70 s. It occurs more frequently in women, but gender differences have reduced in recent years. It also occurs more frequently in women internationally and is suggested to be related to hormones. Gallbladder cancer occurs frequently in Chilean women. India, Eastern Europe, and East Asia are known to be areas with high incidences. There have been reports of many risk factors related to region and race, but molecular biology as well as epidemiological studies have not advanced yet. Future research is anticipated to develop preventive medicine for gallbladder cancer.
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