| Theme |
Cytokines and Dialysis Treatment |
| Title |
Cytokine abnormalities related to pathogenesis of cardiovascular disease in hemodialysis patients |
| Author |
Tetsuo Shoji |
Department of Metabolism, Endocrinology and Molecular Medicine, Osaka City University Graduate School of Medicine |
| Author |
Yoshiki Nishizawa |
Department of Metabolism, Endocrinology and Molecular Medicine, Osaka City University Graduate School of Medicine |
| [ Summary ] |
Atherosclerosis and malnutrition are the two most important determinants of mortality risk in the hemodialysis population. Inflammation is also commonly involved in these conditions. Blood levels of inflammatory cytokines are generally elevated in hemodialysis patients. Adipocyte-derived adipocytokines are also elevated. This article summarizes recent findings that changes in plasma cytokine levels and related gene polymorphisms are closely related to atherosclerosis and future risk of cardiovascular events in the dialysis population. |