| [ Summary ] |
The major cause of death in uremic patients is cerebro-vascular disorders. Uremia induces various kinds of myocardial damage, such as ischemic heart disease, hypertensive cardiomyopathy, uremic pericarditis, and uremic cardiomyopathy. Several uremic substances have been thought to cause these uremic heart diseases. Hyper-homocystinemia is thought to cause ischemic heart disease, and hyper-homocystinemia is caused by folate deficiency, vitamine B6 deficiency and / or vitamine B12 deficiency. Angiotensin II is an another uremic substance which induces hypertensive cardiomyopathy and uremic pericarditis. Uremic cardiomyopathy may be caused by secondary hyperparathyroidism, carnitine deficiency, amyloid deposition, iron overdosage, and some cytokines, which are stimulated by contact with the dialyser. |