| Theme |
Pathophysiology and Treatment of Deranged Lipid Metabolism in Chronic Renal Failure |
| Title |
Lipoprotein metabolism in patients following kidney transplantation |
| Author |
Tatsuya Nakatani |
Depertment of Urology, Osaka City University Medical School |
| Author |
Keisuke Yamamoto |
Depertment of Urology, Osaka City University Medical School |
| Author |
Taketoshi Kishimoto |
Depertment of Urology, Osaka City University Medical School |
| [ Summary ] |
Cardiovascular disease is the second largest cause of death in kidney transplant patients. Mortality from cardiovascular disease is about 10 times higher than in the corresponding general population. Lipoprotein metabolism disorders are among the risk factors for cardiovascular disease. Hypercholesterolemia and hypertriglyceridemia are common after kidney transplantation. There were several possible contributing causes, including immunosuppressive agents, obesity, diabetes and renal disfunction. High density lipoprotein cholesterol concentrations in hemodialysis patients may be lowered, but they elevate to normal ranges or higher after kidney transplantation. Lipoprotein(a) concentrations, which are one of the markers of arterioscrerosis, return to the normal range after kidney transplantation. We described the mechanism and special features of lipoprotein metabolism which take place after kidney transplantation. |