INTESTINE Vol.25 No.4(8)


連載名 第28回大腸Ⅱc研究会 優秀演題
題名 開大の目立たないⅡ型様pit patternを基盤とする鋸歯状病変癌化の1症例
発刊年月 2021年 12月
著者 原田 英嗣 秋田赤十字病院消化器病センター/徳島赤十字病院消化器内科
著者 田中 義人 秋田赤十字病院消化器病センター/岩手医科大学医学部病理診断学講座
著者 松下 弘雄 秋田赤十字病院消化器病センター
著者 吉川 健二郎 秋田赤十字病院消化器病センター
著者 高木 亮 秋田赤十字病院消化器病センター
著者 加藤 文一朗 秋田赤十字病院消化器病センター
著者 佐々木 真 秋田赤十字病院消化器病センター
著者 橋本 大志 秋田赤十字病院消化器病センター
著者 菅井 有 岩手医科大学医学部病理診断学講座
著者 上杉 憲幸 岩手医科大学医学部病理診断学講座
著者 永塚 真 岩手医科大学医学部病理診断学講座
著者 山野 泰穂 岩手医科大学医学部病理診断学講座
【 要旨 】 症例は70歳代,男性.下部消化管内視鏡検査で横行結腸に長径8mm大の0-Ⅱa病変を認めた.色素拡大観察で病変の大部分は,開大や星芒状所見が目立たないⅡ型様pit patternで占められており,また病変の一部には径2mm程度の類円形の異質な領域が認められ,同部はⅤI型pit patternと診断した.またクリスタルバイオレット(CV)染色にて,前述2領域間に,やや大柄で複雑化した星芒状pitが存在する,わずかな領域を認識した.以上の所見から,なんらかの鋸歯状病変を基盤とし,病変内の一部に異型度の変化をきたし,その領域の大部分に癌化を生じた病変と考えた.深達度はTisと判断し,診断的治療目的に内視鏡的粘膜切除術(endoscopic mucosal resection;EMR)を行った.病理診断はModerately differentiated adenocarcinoma(tub2) in sessile serrated adenoma/polyp,depth pTis,Ly0,V0,pHM0,pVM0であった.
Series
Title Discontinuation of infliximab in patients with ulcerative colitis in remission (HAYABUSA): a multicentre, open-label, randomised controlled trial
Author Eiji Harada Department of Gastroenterology, Akita Red Cross Hospital / Department of Gastroenterology, Tokushima Red Cross Hospital
Author Yoshihito Tanaka Department of Gastroenterology, Akita Red Cross Hospital / Department of Molecular Diagnostic Pathology, Iwate Medical University, School of Medicine
Author Hiro-o Matsushita Department of Gastroenterology, Akita Red Cross Hospital
Author Kenjiro Yoshikawa Department of Gastroenterology, Akita Red Cross Hospital
Author Ryo Takagi Department of Gastroenterology, Akita Red Cross Hospital
Author Bunichiro Kato
Author Shin Sasaki Department of Gastroenterology, Akita Red Cross Hospital
Author Hiroshi Hashimoto Department of Gastroenterology, Akita Red Cross Hospital
Author Tamotsu Sugai Department of Molecular Diagnostic Pathology, Iwate Medical University, School of Medicine
Author Noriyuki Uesugi Department of Molecular Diagnostic Pathology, Iwate Medical University, School of Medicine
Author Makoto Eizuka Department of Molecular Diagnostic Pathology, Iwate Medical University, School of Medicine
Author Hiro-o Yamano Department of Gastroenterology and Hepatology, Sapporo Medical University School of Medicine
[ Summary ] We present a case of carcinoma in sessile serrated adenoma/polyp based on Type II-like pit pattern with inconspicuous ductal dilatation. A follow-up colonoscopy was performed for a 70-year-old man. The patient presented with a Type IIa lesion (8mm in diameter) in the transverse colon. On magnifying chromoendoscopy, most parts of the lesions had a Type II-like pit pattern, characterized by inconspicuous dilatation and star-like findings. Moreover, some parts showed heterogeneity with a diameter of 2 mm; these parts were evaluated to be Type VI pit pattern. In addition, crystal violet staining recognized a small region where a slightly large and complicated star-like pit existed between the above two regions. We considered that a few serrated lesions had become malignant in most of their areas with changes in the atypia degree. The depth of invasion was classified as Tis. Endoscopic mucosal resection was performed. The pathological diagnosis was moderately differentiated adenocarcinoma (tub2) in sessile serrated adenoma/polyp; depth, pTis; Ly0; V0; pHM0; pVM0.
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