| Theme | Molecular biology of colorectal tumors | |
|---|---|---|
| Title | UC-related tumorigenesis and molecular abnormality | |
| Publish Date | 2018/09 | |
| Author | Tomomitsu Tahara | Department of Gastroenterology, Fujita Health University School of Medicine |
| Author | Ichiro Hirata | Department of Gastroenterology, National Federation of Health Insurance Societies Osaka-Central Hospital |
| Author | Tomoyuki Shibata | Department of Gastroenterology, Fujita Health University School of Medicine |
| Author | Naoki Ohmiya | Department of Gastroenterology, Fujita Health University School of Medicine |
| [ Summary ] | Chronic inflammation plays an important role in the development of ulcerative colitis (UC) associated colorectal cancer (UCAC). Accelerated age-related DNA methylation has been observed in the colonic mucosa in UC patients with neoplasia, suggesting that DNA methylation may be an important initial mechanism of UC-related tumorigenesis. On the other hand, somatic mutations in the tumorsuppressor gene TP53 are frequently observed in UCAC in early stage disease. More detailed interactive mechanisms of age-related DNA methylation and TP53 mutation in UC-related tumorigenesis remain to be clarified. | |