| Theme |
Development of surveillance methods for colitic cancer -- From pit pattern to molecular biology |
| Title |
Molecular events (genetic mutations and instability) in colitis-dysplasia-carcinoma sequence |
| Author |
Takashi Yao |
Department of Anatomic Pathology, Graduate School of Medical Sciences, Kyushu University |
| Author |
Masaki Gushima |
Department of Anatomic Pathology, Graduate School of Medical Sciences, Kyushu University |
| Author |
Masazumi Tsuneyoshi |
Department of Anatomic Pathology, Graduate School of Medical Sciences, Kyushu University |
| [ Summary ] |
Ulcerative colitis (UC) associated neoplasia has different clinicopathological features including mucin profiles from sporadic adenoma-carcinoma sequences (ACS), which reflect different associated molecular events. APC and K-ras mutations are common in sporadic ACS, however, they are not common in UC-associated neoplasia. p53 mutations are frequently present in both UC-associated neoplasia and ACS. However, this is an earlier event in UC-associated neoplasia than in ACS. Although there previously seemed to be a high incidence of microsatellite instability in UC-associated neoplasia, recent reports indicate a low incidence. Chromosomal instability is thought to be related to carcinogenesis in UC-associated neoplasia. Detection of this instability may also be useful for investigating high risk groups in long term UC patient populations. Thus, analysis of molecular events is expected to be useful for earlier diagnosis of UC-associated neoplasia. |