Theme |
Hepatitis B : Towards the Elimination |
Title |
The Japanese Society of Hepatology Guidelines for Hepatitis B Virus Infection Management |
Author |
Masayuki Kurosaki |
Department of Gastroenterology and Hepatology, Musashino Red Cross Hospital |
Author |
Namiki Izumi |
Department of Gastroenterology and Hepatology, Musashino Red Cross Hospital |
[ Summary ] |
The ultimate goal of antiviral therapy for chronic hepatitis B is HBs antigen clearance. A finite duration of therapy with pegylated interferon could achieve high rates of HBs antigen clearance among responders ; however, the percentage of responders is limited to 20 % to 40 %. Entecavir and tenofovir administration could achieve a high rate of HBV DNA negativity, meanwhile the rate of HBs antigen clearance is also high in tenofovir treated patients. In patients with a suboptimal response, combination therapy using tenofovir plus entecavir or lamivudine is recommended. |