| Theme |
Malignant Biliary Stricture -- Recent Advancements on Diagnosis & Treatment |
| Title |
Pathology of Malignant Biliary Stenosis |
| Author |
Nobuyuki Ohike |
Division of Pathology, Showa University Fujigaoka Hospital |
| Author |
Yoshimitsu Ohgiya |
Department of Radiology, Showa University School of Medicine |
| Author |
Takeshi Aoki |
Division of Gastroenterological & General Surgery, Department of Surgery, Showa University School of Medicine |
| Author |
Hitoshi Yoshida |
Division of Gastroenterology, Department of Medicine, Showa University School of Medicine |
| Author |
Seiya Hajikano |
Department of Pathology, Showa University School of Medicine |
| Author |
Nobukazu Shima |
Department of Pathology, Showa University School of Medicine |
| [ Summary ] |
Pathological findings of extrahepatic bile duct cancer which often result in malignant biliary stenosis are described. The general features of intraductal papillary neoplasms in the bile duct (IPNB), a sub-classification of ampullary cancer, a differential diagnosis between distal bile duct cancer and pancreatic cancer with bile duct invasion are briefly commented on also. There seems to be a trend to comprehensively consider all neoplasms occurring in the pancreatobiliary system to be the above mentioned. This is because ordinary tubular adenocarcinomas of the pancreatobiliary system share similar histological findings. Moreover, there are analogous neoplasms in the bile duct, gallbladder, and Vaterʼs papilla, termed IPNB, intra-cholecystic papillary-tubular neoplasms (ICPN), and intra-ampullary papillary-tubular neoplasms (IAPN), in addition to intraductal papillary mucinous neoplasms (IPMN) of the pancreas. However, further investigations are necessary to recognize the similarities and differences between these conditions. Biological studies focused on cell lineages and genetic events must be conducted as well. |