| Theme |
Diagnosis and Treatment of Scirrhous Gastric Cancer -- Current Status and Future Prospects |
| Title |
Molecular Mechanism of Development and Progression in Scirrhous Gastric Cancer |
| Author |
Kazuhiro Sentani |
Department of Molecular Pathology, Hiroshima University Graduate School of Biomedical Sciences |
| Author |
Naohide Oue |
Department of Molecular Pathology, Hiroshima University Graduate School of Biomedical Sciences |
| Author |
Naoya Sakamoto |
Department of Molecular Pathology, Hiroshima University Graduate School of Biomedical Sciences |
| Author |
Wataru Yasui |
Department of Molecular Pathology, Hiroshima University Graduate School of Biomedical Sciences |
| [ Summary ] |
Scirrhous gastric cancer is characterized by a poor prognosis and a biological interaction between cancer cells and fibroblasts. In the course of development and progression of scirrhous gastric cancer, various alterations of oncogenes, tumor suppressor genes, DNA repair genes, growth factors / receptors, cell cycle regulators and cell adhesion molecules are accumulated. These can be biological markers of malignancy for molecular-pathological diagnosis. The gene expression profilings, based on microarray analysis, serial analysis of gene expression (SAGE) or Escherichia coli ampicillin secretion trap (CAST), have great potential for differentiating the characteristics of gene expression in individual cancers and predicting biological behavior and chemosensitivity. Genetic polymorphism is an important determinant of the endogenous cause of cancer and can be used as a marker for gastric cancer risk that will directly connect with personalized cancer prevention. Many microRNAs are up-regulated and down-regulated, and some of these are associated with histology and cancer progression. Advances in our understanding of the genetic and molecular bases lead to improved diagnosis, personalized medicine and prevention of scirrhous gastric cancer. |