| Theme |
Nutrition Therapy for Liver Diseases |
| Title |
Inhibitory Effects of Branched-chain Amino Acids on Hepatocarcinogenesis in Hepatitis C Virus-associated Cirrhosis |
| Author |
Masahiro Kobayashi |
Department of Hepatology, Toranomon Hospital |
| Author |
Hiromitsu Kumada |
Department of Hepatology, Toranomon Hospital |
| [ Summary ] |
Branched-chain amino acid (BCAA) granules have been used to reverse hypoalbuminemia in cirrhotic patients. In addition, it is thought that BCAA may decrease the risk of hepatocellular carcinoma (HCC). It is reported that BCAA improves glucose metabolism by promoting glucose uptake and glycogen synthesis in insulin free conditions within skeletal muscle. It is also hypothesized that these improvements in glucose metabolism may be related to anti carcinogenic effects. A randomized control trial for use of BCAA in treating disease progression and development of liver related complications in patients with HCV-related cirrhosis was conducted. Although development rates for liver related complications, including HCC, were not significant in the BCAA treated group or the untreated group, rates were markedly decreased in patients whose Fischer's ratio improved to as high as 3. 4 after administration of BCAA. These results may indicate that utilization of BCAA in skeletal muscle and improvements in Fischer's ratio may be necessary to exhibit anti carcinogenic effects in patients with HCV related cirrhosis. |