| Theme |
Oxidative Stress and the Liver |
| Title |
Thioredoxin, a Marker of Oxidative Stress |
| Author |
Shugo Ueda |
Department of Experimental Therapeutics, Translational Research Center, Kyoto University Hospital |
| Author |
Makiko Narita |
Redox BioScience Inc. |
| Author |
Junji Yodoi |
Department of Experimental Therapeutics, Translational Research Center, Kyoto University Hospital / Redox BioScience Inc. / Department of Biological Responses, Institutre for Virus Research, Kyoto University |
| [ Summary ] |
Markers of oxidative stress include anti-oxidants as well as chemical adducts caused by reactive oxygen species (ROS). Thioredoxin, a redox-regulating molecule having -Cys-Gly-Pro-Cys- in its active site, plays an important role in regulating intracellular redox status and signal transduction. The serum or plasma levels of thioredoxin measured with the enzyme-linked immunosorbent assay (ELISA) system are regarded as a good marker of oxidative stress. The level increases in patients with oxidative stress-related diseases, such as viral infection and inflammatory disease. The elevated levels of thioredoxin correlate with the severity and poor prognosis of the diseases. Furthermore, since thioredoxin is a promising target for regulating oxidative stress related diseases, a translational research project administrating recombinant thioredoxin is in progress. |