臨牀消化器内科 Vol.19 No.9(6-6)


特集名 イレウス診療のpitfall -- いつ外科に送るか
題名 麻痺性イレウス:症例に学ぶ (6) Nonocclusive mesenteric ischemia (NOMI)
発刊年月 2004年 08月
著者 加藤 久晶 順天堂大学医学部附属順天堂浦安病院外科
著者 福永 哲 順天堂大学医学部附属順天堂浦安病院外科
著者 木所 昭夫 順天堂大学医学部附属順天堂浦安病院外科
【 要旨 】 非閉塞性腸管虚血症 (nonocclusive mesenteric ischemia; NOMI) は腸間膜血管に器質的閉塞が存在しないにもかかわらず,腸管の不可逆的虚血により壊死を生じる疾患である.発症は緩徐なことが多く,かつ特異的な症状をもたないため,所見が顕在化するころには,すでに腸管が壊死に陥っており緊急手術を要する場合も少なくなく,NOMIの救命を困難なものとしている.よって,高齢者で心血管疾患や脱水状態の病態下にある患者が,腹痛や血性水様性下痢などの腸管虚血を疑わせる臨床症状を呈する場合は,常に本症を念頭に診療にあたる必要がある.
Theme Diagnosis and Treatment of Intestinal Obstruction: Timing in Consulting a Surgeon
Title Nonocclusive Mesenteric Ischemia
Author Hisaaki Kato Department of Surgery, Juntendo University Urayasu Hospital
Author Tetsu Fukunaga Department of Surgery, Juntendo University Urayasu Hospital
Author Akio Kidokoro Department of Surgery, Juntendo University Urayasu Hospital
[ Summary ] Nonocclusive mesenteric ischemia (NOMI) is an intra-abdominal catastrophe related to bowel necrosis in the absence of organic mesenteric vascular occlusions. Mesenteric vasospasms are a cause of NOMI, which may be induced by excessive sympathetic activity with cardiogenic, hypovolemic shock, digitalis toxicity, or common factors which decrease cardiac output with splanchnic vasoconstriction. Because physical, roentgenographic findings, and laboratory tests are not specific enough until after intestinal infarction has occurred, it is difficult to make an early diagnosis of NOMI, producing high mortlity rates. Early arteriography in patients suspected of having NOMI offers a chance for early diagnosis and pharmacological treatment prior to the onset of intestinal infarction. If the peritoneal signs fail to resolve with pharmacological treatment, immediate laparotomy is indicated. The aim of this operation is to assess bowel viability, resect obviously infracted bowel segments, and determine whether a second operation after twenty four hours is necessary. The purpose of this article is to summarize the pathophysiology, diagnosis and treatment modalities for NOMI and present case reports.
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