| Theme |
H.pylori Negative Upper Gastroenterological Diseases; Increasing of Their Incidence in the 21st Century |
| Title |
Helicobacter pylori Negative Gastric Cancer in Japan |
| Author |
Shunji Kato |
Surgery for Organ Function and Biological Regulation, Nippon Medical School |
| Author |
Norio Matsukura |
Surgery for Organ Function and Biological Regulation, Nippon Medical School |
| Author |
Zenya Naito |
Integrative Pathology, Nippon Medical School |
| Author |
Takashi Tajiri |
Surgery for Organ Function and Biological Regulation, Nippon Medical School |
| [ Summary ] |
Even though detection systems for Helicobacter pylori (H.pylori) infection-negative status in patients have not been established, only 2% of cases out of all gastric cancer patients are reported to be H.pylori negative, when there is pathological analysis of the gastric mucosa after gastrectomy. Also only 2% of the early gastric cancer patients were reported to be H.pylori negative as detected by multiple detection systems. In our experience, only 4% of almost 800 primary gastric cancer patients were H.pylori negative, displaying neither the anti-H.pylori antibodies noratrophy in the gastric mucosa detected by biomarkers for pepsinogen I and pepsinogen I/II ratio. On the other hand, the Epstein-Barr (EB) virus is related to cases of gastric carcinogenesis, in affected populations reported, and is approximately 2 to 16% of these cases world wide. In our study for cardiac gastric cancers or secondary cancers in the remnant stomach, EB virus tested positive in 34% of the cases, in which, one forth were H.pylori negative patients. Both EB virus and H.pylori negative cases were 11% of the total. A small fraction of the gastric cancer patients displayed multi-factorial carcinogenesis without infection. |