| Theme |
Laser Endoscopy in Theory and Practice --Perspective of GI Endoscopy in the 21st Century |
| Title |
Progress in Photodynamic Therapy for Gastric Cancer |
| Author |
Seishiro Mimura |
Department of Gastroenterology, Osaka Medical Center for Cancer and Cardiovascular Diseases |
| [ Summary ] |
Progress in photodynamic therapy (PDT) for gastric cancer and the clinical outcome were presented in this paper. Our originals were as follows. 1) We included the whole lesion and a 5mm margin in the irradiation field. 2) We established the standard light dose to be 90J/cm2 for an argon dye laser and 60J/cm2 for a pulse laser. 3) The size of cancerous lesion curable by PDT was expanded from 7cm2 in area to 13cm2 by employing a new model of the excimer dye laser. 4) The depth of cancer invasion which could be treated by PDT was improved from about 4mm in depth i.e. the superficial part of submucosal layer(SM-1) to more than lOmm in depth i.e. the proper muscular layer. 5) We employed a side-viewing fiberscope for gastric PDT to irradiate the lesion at a right angle. 6) We developed an endoscopic device for photoradiation in PDT. The device achieved prompt and accurate irradiation. 7) We designed a simple cut quartz fiber with a special spring thickened toward the end. As a result of these improvements a higher cure rate was obtained by lower light dose irradiation. |