| 特集名 | sm癌の脈管侵襲と転移 | |
|---|---|---|
| 題名 | 大腸壁内リンパ管の微細分布とリンパ流 -- 組織化学・電顕的観察 | |
| 発刊年月 | 2001年 09月 | |
| 著者 | 三浦 真弘 | 大分医科大学医学部解剖学講座第一 |
| 著者 | 豊田 弘之 | 大分共立病院消化器内科 |
| 著者 | 加藤 征治 | 大分医科大学医学部解剖学講座第一 |
| 【 要旨 】 | 要旨はありません。 | |
| Theme | Vessel invasion and metastasis in colorectal submucosal cancer | |
|---|---|---|
| Title | Fine distribution of intramural lymphatic vessels in the large intestines of monkeys and their lymph flow : An enzyme-histochemical and electron microscopic observation | |
| Author | Masahiro Miura | Department of Anatomy, Oita Medical University |
| Author | Hiroyuki Toyoda | Department of Gastroenterology, Oita Joint Medical Center |
| Author | Seiji Kato | Department of Anatomy, Oita Medical University |
| [ Summary ] | In the present study, the fine distribution and structure of intramucosal lymphatics in the colon of the Japanese monkey (Macaca fuscata) were examined enzyme-histochemically with light and electron microscopy. Whole mount preparations of each tissue layer, pealed from the colonic wall, and cryostat sections, were stained using 5'-Nase-ALPase double staining. 5'-Nase-positive lymphatics appeared as extensive networks in the lamina propria mucosae (LPM), lamina submucosae (MS), muscularis propria (MP) and subserosal layers. Some of these were found to be closely associated with ALPase-positive blood vessels. Double-layered lymphatic networks were locally observed near the inner and outer surfaces of lamina muscularis mucosae (LMM). Numerous slender lymphatics without valve-like structures, coursing vertically, were seen in the intercryptal region. All the lymphatics originated from horizontal networks in the deep LPM. In general, they had scarcely any communicating branches in the superficial layer of LPM, except in the cecum and recto-sigmoid colon. In the cecum and recto-sigmoid colon, fine, dense lymphatic networks were locally observed in the most superficial layer of LPM. On the other hand, lymphatic networks of the deep LPM were characterized by a regular mesh-like network on the basis of the penetrating point on the LMM. These lymphatic networks closely communicated with a irregular horizontal ones, which consisted of tubulo-saccular lymphatics and were directly located under the LMM, via the penetrating branch. The latter showed a lymphatic network with obvious valve-like structures and had numerous enlarged blind-endings. The present study demonstrated, using enzyme-histochemistry, the precise distribution of 5'-Nase-positive initial lymphatics, by using whole mount preparations in the laminar layer of the monkey colon. Our findings suggest that rich initial quantities of lymphatics in LPM may play an important role in the absorption of tissue fluids and various free cells. |
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