| 特集名 | Villous Tumor | |
|---|---|---|
| 題名 | 大腸villonous tumor --定義と問題点 | |
| 発刊年月 | 2001年 01月 | |
| 著者 | 原岡 誠司 | 福岡大学医学部病理学教室第一講座 |
| 著者 | 岩下 明徳 | 福岡大学筑紫病院病理部 |
| 著者 | 八尾 隆史 | 九州大学大学院医学研究院形態機能病理学分野(2病理) |
| 【 要旨 】 | 要旨はありません。 | |
| Theme | Villous Tumor | |
|---|---|---|
| Title | Vilious tumor of the large intestine -- definition and diagnostic problems | |
| Author | Seiji Haraoka | Department of Pathology, School of Medicine, Fukuoka University |
| Author | Akinori Iwashita | Department of Pathology, Chikushi Hospital, Fukuoka University |
| Author | Takashi Yao | Department of Anatomic Pathology, Graduate School of Medical Sciences, Kyushu University |
| [ Summary ] | A clinicopathological study of villous tumors of the large intestine was done on forty four resected specimens obtained from forty four patients. Villous tumors of the large intestine were defined as macroscopic in elevation, with villous or fine granular surfaces and with microscopic protrusions, more than 90% of which were composed of villous patterns. The results obtained were as follows: 1) The average age was 64.7 years and the male to female ratio was five to six. Villous tumors were most frequently observed in rectosigmoid colons (34 of 44 cases), and were also found in the cecum and appendix (6 of 44 cases). 2) Thirty three out of forty four tumors were sessile in shape. Four had ulcerations on the surface, consisting of cancerous tissue. The largest average diameter was 7.0cm, ranging from 2.2 to 17.0cm, and that of tumors composed of carcinoma or of those having carcinoma component in part was 7.8cm, which was much larger than those having no cancerous tissue, with an average diameter of 5.1cm. 3) Villous tumors studied were histologically classified into two groups as follows ; twenty four cases of adenocarcinoma of low grade malignancy, in which the tumor was composed of extremely well differentiated adenocarcinoma, and twenty cases of villous adenoma, including seven cases in which the tumor was partly composed of carcinoma and thirteen cases without carcinoma components. 4) Overexpression of p53 protein was revealed in three out of eleven cases (27%) of adenocarcinomas of low grade malignancy. None of the eight cases of villous adenoma revealed p53 overexpresslon. 5) Histological diagnosis made on biopsy specimens was correct in only nine out of twenty seven cases examined (33%). In conclusion, this work showed the possibility that villous tumors of the large intestine are composed of two groups: villous tumors of the potentially or substantially malignant type, and villous adenomas of composed of subtypes or special types. It was also shown that it is difficult to make a correct histological diagnosis of the tumor from biopsy specimens. In addition, brief discussion was made of p53 expression. |
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